ChemicalBook > CAS DataBase List > MYXOTHIAZOL

MYXOTHIAZOL

Product Name
MYXOTHIAZOL
CAS No.
76706-55-3
Chemical Name
MYXOTHIAZOL
Synonyms
Myxothiazo;MYXOTHIAZOL;5-dimethoxy-4-methyl-;myxothiazolfrommyxobacterium;MYXOTHIAZOL, VIAL WITH 10 MG*;MYXOTHIAZOL FROM MYXOBACTERIUM 95%;MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS;myxothiazol from myxobacterium*myxococcus fulvus;7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide;2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
CBNumber
CB0453976
Molecular Formula
C25H33N3O3S2
Formula Weight
487.68
MOL File
76706-55-3.mol
More
Less

MYXOTHIAZOL Property

Boiling point:
679.6±65.0 °C(Predicted)
Density 
1.158±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow
pka
14.07±0.50(Predicted)
More
Less

Safety

Hazard Codes 
T+
Risk Statements 
28
Safety Statements 
28-36/37-45
RIDADR 
UN 3462 6.1/PG 1
WGK Germany 
3
RTECS 
QH7580000
F 
10
HazardClass 
6.1(b)
PackingGroup 
III
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
T5580
Product name
Myxothiazol
Purity
from Myxococcus fulvus Mx f85, ≥98% (HPLC)
Packaging
1mg
Price
$111
Updated
2024/03/01
Sigma-Aldrich
Product number
T5580
Product name
Myxothiazol
Purity
from Myxococcus fulvus Mx f85, ≥98% (HPLC)
Packaging
5mg
Price
$444
Updated
2024/03/01
American Custom Chemicals Corporation
Product number
INB0001302
Product name
MYXOTHIAZOL
Purity
98.00%
Packaging
5MG
Price
$505.27
Updated
2021/12/16
ChemScene
Product number
CS-0043613
Product name
Myxothiazol
Purity
≥99.0%
Packaging
5mg
Price
$730
Updated
2021/12/16
ChemScene
Product number
CS-0043613
Product name
Myxothiazol
Purity
≥99.0%
Packaging
1mg
Price
$290
Updated
2021/12/16
More
Less

MYXOTHIAZOL Chemical Properties,Usage,Production

Uses

Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.

Definition

ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S

Biochem/physiol Actions

Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.

MYXOTHIAZOL Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

MYXOTHIAZOL Suppliers

China 14 Germany 1 South Korea 1 Switzerland 1 United Kingdom 1 United States 6 Global 24

76706-55-3, MYXOTHIAZOLRelated Search:

2-Isopropyl-4-methyl thiazole 3-METHYL-1,5-HEPTADIENE 1,5-HEXADIEN-3-OL 2-Ethyl-4-methyl thiazole 4-METHYL-1-PENTEN-3-OL 2,4-Dimethylthiazole TRANS-2-METHYL-4-HEXEN-3-OL 2-isopropylthiazole 2-ETHYLTHIAZOLE 1,5-HEPTADIEN-4-OL 4-METHYL-1,5-HEPTADIENE MYXOTHIAZOL

  • MYXOTHIAZOL, FROM MYXOCOCCUS FULVUS
  • MYXOTHIAZOL
  • 5-dimethoxy-4-methyl-
  • 7-(2’-(1,6-dimethyl-2,4-heptadienyl)(2,4’-bithiazol)-4-yl)-6-heptadienamide
  • myxothiazol from myxobacterium*myxococcus fulvus
  • MYXOTHIAZOL, VIAL WITH 10 MG*
  • MYXOTHIAZOL FROM MYXOBACTERIUM 95%
  • myxothiazolfrommyxobacterium
  • 2,6-Heptadienamide, 7-(2'-((1S,2E,4E)-1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)-
  • 2,6-Heptadienamide, 7-(2'-(1,6-dimethyl-2,4-heptadienyl)(2,4'-bithiazol)-4-yl)-3,5-dimethoxy-4-methyl-
  • Myxothiazo
  • 2,6-Heptadienamide, 7-[2'-[(1S,2E,4E)-1,6-dimethyl-2,4-heptadien-1-yl][2,4'-bithiazol]-4-yl]-3,5-dimethoxy-4-methyl-, (2E,4R,5S,6E)-
  • 76706-55-3
  • C25H33N3O3S2
  • Antibiotics G-M
  • Antibiotics
  • Antibiotics A to Z
  • BioChemical
  • Inhibits an EnzymeNitric Oxide and Cell Stress
  • Mitochondrial InhibitorsAntibiotics
  • Antibiotics
  • Antibiotics A to
  • Antibiotics G-MAntibiotics
  • AntifungalAntibiotics
  • Cell Stress
  • Chemical Structure Class
  • Mechanism of Action
  • Peptides
  • Spectrum of Activity